Challenge:  I realize this can't really be Spuffy, but some Spike-Buffy interaction centering on Spike's outburst in "Pangs": "You! You made a bear!"

“Most annoying moment.”

“Are you kidding?”

“What?  You suggesting I’m annoying all the time?”

“Don’t pout.  I didn’t say you were always annoying.  It’s just that one particular moment stands out.”

“I’m intrigued.  When, pray tell, was this moment?”

“Thanksgiving, freshman year.  Fighting the Chumash warrior?  ‘You made a bear!’  Seriously, what was that?  Could you have been less helpful?”

Spike had the decency to look abashed.  

“I so wanted to slap you, but I was otherwise occupied.”